Managing PERT Shortages: Creon® Alternative (Adults) – Imported Pangrol®

South Yorkshire ICB continues to work closely with local hospitals and Community Pharmacy South Yorkshire to support access to Pancreatic Enzyme Replacement Therapy (PERT).

Key Points:

• Creon® (UK-licensed) should be prescribed as the first-line option. Stock is released to wholesalers three times per month.

• If Creon® is unavailable and a patient is expected to run out within 10 days, Pangrol® may be prescribed for adult patients, in line with local approval.

• Pangrol® can now be ordered directly by community pharmacies from the Oxford Pharmacy Store (OPS), with next-day delivery for orders placed by 2pm. This centralised stock is underwritten by University Hospital Southampton to help reduce lead times.

• Please refer to local guidance for any additional arrangements agreed with specific trusts.

Attached: Updated Guidance for Pharmacy Contractors

• Guidance on prescribing and ordering unlicensed imported Pangrol® (adults only)
  Pangrol -OPS information_FINAL

• Pangrol® order form –
  OPS-FORM-005 New Customer Verification Form v12 November 2024 – PDF
  OPS-FORM-005_New_Customer_Verification_Form_v12_November_2024 – Word

• PERT – Information for Patients_FINAL

If community pharmacies encounter any issues using OPS, please contact emily.parsons9@nhs.net so the ICB can assist and update the guidance as needed.